There are six evil consequences in indulging in gambling:
(i) the winner begets hate,
(ii) the loser grieves for lost wealth,
(iii) loss of wealth,
(iv) his word is not relied upon in a court of law,
(v) he is despised by his friends and associates,
(vi) he is not sought after for matrimony; for people would say he is a gambler and is not fit to look after a wife [spouse]...
Gambling is discouraged by the Buddha, as we can see in the Sigalovada Sutta. What are the six channels for dissipating wealth which Buddha does not pursue?
(a) indulgence in intoxicants which cause infatuation and heedlessness;
(b) sauntering in streets at unseemly hours;
(c) frequenting theatrical shows;
(d) indulgence in gambling which causes heedlessness;
(e) association with evil companions;
(f) the habit of idleness...
Furthermore, Buddhists are forbidden from taking intoxicants, such as drugs. And the physiological effects of gambling are the same as crack cocaine and cocaine (stimulants) and heroin (numbing, forgetting and escaping from problems, stress, pressure).